Recent Advances in the Application of Marine Natural Products as Antimicrobial Agents

Preclinical Drug Entities in Clinical Trial Pipeline from Marine Source

Author(s): Suganya Kannan*, Karvannan Sevugamurthi, Jeyakumar Balakrishnan, Ambujam Govindasamy and Murugan Marudhamuthu

Pp: 369-388 (20)

DOI: 10.2174/9789815080148123030019

* (Excluding Mailing and Handling)


The massive increase in the world’s population has placed an undue strain on the available resources for pharmaceuticals. As a result, drug producers are constantly on the lookout for new resources that will allow them to build effective and safe pharmaceuticals to meet the growing demands of the world’s population. However, three fourth of the earth’s surface is covered by the marine environment, studies into the pharmacology of marine creatures have been limited, and much of what has been discovered is still undiscovered. The marine environment is a plethora and diversified source of novel medications to treat important diseases like cancer and malaria, among others. Marine natural products have distinct, previously unexplored diversifications as well as a diverse range of intriguing biological potentialities that are characterized by unique mechanisms of action. Recently discovered and preclinically researched marine bioactive antimicrobials are the focus of this chapter.

Keywords: Antibiotic-resistant bacteria, Antimicrobials, Aquaculture, Bioactive chemicals, Biological potentialities, Cancer drug, Clinical investigations, Clinical trial, Cytarabine, Cytotoxicity, Desertomycin G, Environmental conditions, Genetic engineering, Marine natural products, Marine origin, Marine sponge, Marine-derived drug, Preclinical to Drug, Preclinical, Secondary metabolites.

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