Brain Tumor Targeting Drug Delivery Systems: Advanced Nanoscience for Theranostics Applications

Theranostics Polymeric Nanoparticles for Brain Tumor Diagnosis and Treatment

Author(s): Sivadas Swathi Krishna, Ardra Thottarath Prasanthan, Nirdesh Salim Kumar, Manish Philip and Vidya Viswanad *

Pp: 60-99 (40)

DOI: 10.2174/9789815079722123010005

* (Excluding Mailing and Handling)


Theranostics, a dual strategy, helps in better tumor imaging, the biodistribution of drugs (the ability to direct therapeutic agents to the tumor site), and understanding the progress and effectiveness of therapy. Theranostics is an emerging technology for the diagnosis and management of brain tumors which differ from peripheral tumors in several ways because of their complexity in the genesis of oncogenes. Several factors must be considered for successful brain tumor-targeted drug delivery. Nanotheranostics for brain cancer therapies have been identified now, and polymeric nanoparticles (PNP) are one of the most efficient and promising nanotechnological platforms. They can be utilized as a new imaging method to optimize chemotherapeutic drug delivery into brain tumors while reducing the drug's dissemination and toxicity in healthy people. Smart carriers and theranostic nanoparticles can diagnose, deliver, and track the therapeutic response synchronized. This chapter gives an insight into superparamagnetic, ultrasound-triggered radionuclide bearing, and fluorescent PNPs as potential theranostic approaches for brain tumor management. 

Keywords: Brain tumor targeting, Fluorescent nanoparticles, Polymeric nanoparticles, Superparamagnetic nanoparticles, Theranostics.

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