Anticancer Immunity: Reviewing the Potential of Probiotics

Probiotic Formulations For Anticancer Immunity

Author(s): Rabinarayan Parhi* and Nirupam Das

Pp: 244-284 (41)

DOI: 10.2174/9789815165135123040013

* (Excluding Mailing and Handling)


Probiotics are defined as “viable microorganisms which, when administered in adequate amounts, promote health benefits on the host”. These health benefits may include maintaining a healthy gut microbiota, reducing cholesterol levels, formation of antimicrobial agents and vitamins, competitive inhibition of pathogenic bacteria in terms of attachment site and nutrition, immunity-boosting, improvement of calcium absorption, preventing constipation, and increased trans-epithelial resistance. Cancer is expressed as the abnormal division and reproduction of cells and has a multifactorial pathology. In mortality, cancer is in second place worldwide, which is evident from the report that one out of every four deaths in the USA is due to cancer. Furthermore, the prevalence of cancer is 24% and 21% for men and women, respectively. Probiotics used in the prevention and treatment of cancer often prevent early death due to complications caused by infection, particularly in GIT. The current article mainly discusses different conventional and non-conventional formulations of probiotics. It also discusses probiotics and immunity against cancer, safety, and current regulation regarding probiotics. 

Keywords: Adaptive immunity, Bilayer tablet, Cancer, Enema, Formulation, Innate immunity, Immunomodulation, Microbiome, Microneedle, Nanocomposite, Nanofiber, Orodispersible film, Probiotics, Suppository.

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