Although commonly used anti-infective vaccines in clinical practice are
generally safe, certain local or systemic adverse reactions related to them may rarely
occur. Actually, considering the general vaccination rates, the incidence of serious skin
reactions (e.g . angioedema, anaphylaxis, Stevens–Johnson syndrome) is very low but
vaccine-associated local cutaneous reactions such as erythema, edema, tenderness and
pain at the injection sites are one of the most common complications of vaccines.
Furthermore, a wide variety of specific or non-specific localized or generalized
cutaneous adverse effects (e.g. lichenoid eruption, granuloma annulare,
pseudolymphoma, erythema nodosum, erythema multiforme, Gianotti-Crosti
syndrome, urticaria, lupus erythematosus, bullous pemphigoid, purpura) have been
reported in the literature related with commonly used anti-infective vaccines. In this
chapter, these adverse cutaneous reactions potentially associated with anti-infective
vaccines were summarized with a comprehensive literature review.
Keywords: Adverse Reaction, Anti-infective Vaccination, Bacillus CalmetteGuérin Vaccine, Complication, Cutaneous, Diphtheria and Pertussis Vaccine, Human Papilloma Virus Vaccine, Hepatitis B Virus Vaccine, Influenza Vaccine, Measles, Meningococcal Vaccine, Mumps and Rubella Vaccine, Pneumococcal Vaccine, Rash, Skin, Side Effect, Tetanus, Vaccine, Varicella Vaccine, COVID19 vaccine.