Phytonutrients in the Treatment of Gastrointestinal Cancer

Plant Peptides in the Treatment of Gastrointestinal Cancer

Author(s): Shabnoor Iqbal, Muhammad Ajmal Shah*, Azhar Rasul, Ajmal Khan, Ahmed Al-Harrasi, Shahid Rasool and Muhammad Naeem Amir

Pp: 263-284 (22)

DOI: 10.2174/9789815049633123010014

* (Excluding Mailing and Handling)


Cancer becomes uncontrolled with conventional therapeutic medications and is, therefore, able to tolerate drug activity, which contributes to increasing the adverse effects during medication therapy. The usage of anti-cancer peptides is a recent clinical technique against cancer cells. The physicochemical characteristics, amino acid composition and the addition to the anti-cancer peptides sequence of chemical groups impact their conformation, net load and secondary structure orientation, which affect the targeted specimen and peptide cell interaction, stability and effectiveness of penetrating peptides. Anti-cancer peptides are formed by replacing cationic amino acid residues with neutral or anionic amino acid residues or by introducing a chemical group, both naturally occurring and modified peptides. Updated peptides improve the potency of cancer treatment. This efficacy has recently allowed anti-cancer peptides to shape medicines and vaccines that were sequentially tested in many phases of clinical testing.

The creation of anti-cancer peptides continues to concentrate on the production of clinically adjusted anti-cancer peptides with a view to decreasing the occurrence of new cancer cases and the mortality rate. The current analysis could help promote the creation of anti-cancer peptides and, in the immediate future, improve successful anticancer peptide therapy. Anti-cancer plant peptides are part of several species of plant inborn immune response systems and are attractive candidates for the care of animals and humans against infections. Anti-cancer plant peptides also display anti-cancer activities and can inactivate a wide variety of cancer cells. Cancer appears to be a worldwide source of elevated morbidity and mortality. There is a dire need to produce novel methods to treat gastric cancer. Anti-cancer plant peptides like cyclotides, thionines, and defensins which have anti-cancer activities, are appealing alternatives. We have summarized the anti-cancer effect of anti-cancer plant peptides with a focus on their mode of activity, efficacy, and selectivity.

Keywords: Anti-cancer, GIT cancer, Natural products, Peptides.

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