Natural products exhibited a profound effect as a template or direct
treatment strategy against TNBC. Implementation of natural products as a
chemotherapeutic or chemo-preventive strategy faces diverse problems and challenges.
Several constraints including selection, identification, and screening of bioactive
components furthermore, preclinical and clinical evaluation, and approval from
regulatory bodies are other hurdles to the application of phytochemicals in targeting
TNBC. Although the natural metabolites possessed the substantial potential to target
the disease along with reinvigorating the health of affected individuals. This chapter
has highlighted the perspectives and controversies associated with herbal medicines
such as consumer preferences, bio-pharmaceutics consideration, HM-HM & HM-CM
interactions, and drug regulations, and discussed the need to introduce natural moieties
as an alternative therapeutic approach against TNBC.