The development of an effective therapeutic approach against TNBC is a
formidable challenge at present. Efficacy and drug resistance issues in response to
adjuvant and neoadjuvant chemotherapy have prompted the development of new
therapeutic regimens. In this concern, the scientific community has started exploring
natural sources including medicinal plants exhibiting anti-cancer activity for their
potent inhibitory potential against TNBC. The comprehensive analysis underlying the
molecular mechanism of action of these natural bio-compounds provided substantial
evidence to subject a few of these for clinical application. This chapter highlighted the
momentous phytoconstituents as a genetic or epigenetic modulator by inducing
demethylation and histone deacetylation in TNBC. Bioactive phytoconstituents
including berberine, luteolin, cantharidin, saikosaponin D, wogonoside, and others
targeted cell proliferation, metastasis, angiogenesis, autophagy, and induced apoptosis
in TNBC. Furthermore, combinational therapy comprising phytoconstituents and
chemotherapeutic drugs was explored to improve the clinical outcome of the disease.
Additionally, drug ability parameters including bioavailability and bio-absorption of
these phytoconstituents were also discussed.
Keywords: Absorption, Berberine, Bioavailability, Cantharidin, Chemosensitization, Combinational therapy, Curcumin, Demethylation, DNMT1, Epigenetic modulator, Gambogic acid, Histone deacetylation, hTERT, Liposome, Luteolin, Microencapsulation, Phytochemicals, Saikosaponin, Solubility, Synergistic effect, Wogonoside.