In triple-negative breast cancers, there exist tumor-specific vulnerabilities
that can be targeted to avoid compensatory adaptation of cancer cells in response to
standard pharmaceutical therapies. Natural moieties are well-known to possess a
multitude of medicinal properties and deserve attention for TNBC prevention and
therapy. To overcome drug resistance and efficacy issues, the exploration of natural
moieties as targeting agents may emerge as dynamic, promising, and new therapeutic
strategies to benefit TNBC patients. This chapter summarizes the role of
polysaccharides, flavonoids, phenols, saponins, and taxanes in targeting TNBC. The
potent role of herbal medicine in targeting molecular signalling pathways with special
emphasis on their ability to target uncontrolled proliferation, metastasis, angiogenesis,
and autophagy has also been discussed. Furthermore, the ability of herbal medicine in
inhibiting PI3K/Akt/mTOR, STAT3, and Wnt/β-Catenin has also been explored.
Combinational therapy comprising chemotherapeutic drugs and active plant
constituents was also explored to overcome the complications of TNBC.
Keywords: Anti-proliferative, Artemisinin, Bruceine, Chemo-sensitization, Chrysosplenol, Ebushicao, Flavonoids, Guggal, Multidrug resistance, Oleuropein, Oroxylin A, Phenols, Plumbagin, Polysaccharides, Pro-apoptotic, Saponins, Taxanes.