Neurodegenerative disease refers to the progressive deterioration of
neurologic function which leads to loss of speech, vision, hearing, and movement. It is
also associated with seizures, eating difficulties, and memory impairment. Natural
products have emerged as potential neuroprotective agents for the treatment of
neurodegenerative diseases due to the enormous adverse effects associated with
pharmacological drugs. Withania somnifera (Ashwagandha) is a traditional Ayurvedic
medicine, used in India as a general tonic. It contains withanolides, and phytochemicals
that may have adaptogenic properties. Studies show that W. somnifera is a
neuroprotective agent and can protect the brain from oxidative stress and inflammation.
This explains its ability to protect from mood disorders. In this review, we have
reviewed the available evidence of W. somnifera and its phytochemicals for
Keywords: Ayurvedic medicine, Chinese medicine, Neurological diseases, Phytochemicals, Withania somnifera.