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The Role of Nitric Oxide in Type 2 Diabetes

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Arginine, Nitric Oxide, and Type 2 Diabetes

Author(s): Parvin Mirmiran, Zahra Bahadoran, Khosrow Kashfi and Asghar Ghasemi *

Pp: 260-283 (24)

DOI: 10.2174/9789815079814122010015

* (Excluding Mailing and Handling)

Abstract

L Arginine (Arg), a semi-essential essential amino acid, has received significant research interest over the last two decades as nitric oxide (NO) precursor. Arg is widely used as a complementary treatment in various NO-disrupted conditions, e.g., hypertension, preeclampsia, and endothelial dysfunction. Here, we provide an overview of the potential efficacy of Arg as a NO precursor and its effects on glucose and insulin homeostasis and diabetes-induced cardiovascular complications.

Keywords: Arginine, Argininosuccinate lyase, Argininosuccinate synthase, Citrulline, Nitric oxide, Nitric oxide synthase, Ornithine aminotransferase, Ornithine transcarbamylase and ornithine decarboxylase, Type 2 diabetes.

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