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The Role of Nitric Oxide in Type 2 Diabetes

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Nitric oxide: A Brief History of Discovery and Timeline of its Research

Author(s): Asghar Ghasemi* and Khosrow Kashfi

Pp: 27-38 (12)

DOI: 10.2174/9789815079814122010005

* (Excluding Mailing and Handling)

Abstract

Nitric oxide (NO) plays a critical role in many physiological and pathological functions in the human body. Following the discovery in 1986-1987 that endothelium-derived relaxing factor (EDRF) is NO, the number of NO-based publications within all fields of medicine has increased exponentially. This report provides a brief historical view of NO-based research, emphasizing the events in the last two decades of the 20th century.

Keywords: Cyclic Guanosine Monophosphate, Endothelial Nitric Oxide Synthase, Endothelium-Derived Relaxing Factor, History, Inducible Nitric Oxide Synthase, Nitric Oxide, Neural Nitric Oxide Synthase, Nitric Oxide Deficiency, Nitric Oxide Donating Agents, Wall Saltpeter.

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