Abstract
Nitric oxide (NO) plays a critical role in many physiological and pathological functions in the human body. Following the discovery in 1986-1987 that endothelium-derived relaxing factor (EDRF) is NO, the number of NO-based publications within all fields of medicine has increased exponentially. This report provides a brief historical view of NO-based research, emphasizing the events in the last two decades of the 20th century.
Keywords: Cyclic Guanosine Monophosphate, Endothelial Nitric Oxide Synthase, Endothelium-Derived Relaxing Factor, History, Inducible Nitric Oxide Synthase, Nitric Oxide, Neural Nitric Oxide Synthase, Nitric Oxide Deficiency, Nitric Oxide Donating Agents, Wall Saltpeter.
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