The Role of Nitric Oxide in Type 2 Diabetes

Pathophysiology of Type 2 Diabetes: A General Overview of Glucose and Insulin Homeostasis

Author(s): Asghar Ghasemi* and Khosrow Kashfi

Pp: 1-26 (26)

DOI: 10.2174/9789815079814122010004

* (Excluding Mailing and Handling)


The prevalence of diabetes is increasing worldwide, and this disease has a tremendous financial burden on most countries. Major types of diabetes are type 1 diabetes and type 2 diabetes (T2D); T2D accounts for 90-95% of all diabetic cases. For better management of diabetes, we need to have a better understanding of its pathophysiology. This chapter provides an overview of glucose homeostasis and the underlying pathophysiology of T2D.

Keywords: β-Cell Dysfunction, Glucose Homeostasis, Insulin, Impaired Glucose Tolerance, Insulin Resistance, Insulin Signaling Pathways, Impaired Fasting Glycemia, Type 2 Diabetes.

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