Regenerative medicine (RM) is defined as a replacement and revival of
human cells, tissues, or organs to reinstate or reconstruct their normal physiology. RM
is regarded as a solution to provide healthy substitutes for a malfunctioning/failed
organ or a tissue. It is emerging as the suitable substitute for organ transplantation.
Transplantation seems impractical due to the limited availability of donors as
significant disparities lie between the number of patients that require transplantation
and the availability of organs from the donor, so there was a gap created. Therefore, to
comply with these needs, RM has emerged as a new science to create biological
replacements and exploit the body's ability of regeneration to recover and sustain
normal function in diseased and damaged tissues. This chapter overviews RM in terms
of adopted strategies, its clinical applications in organ engineering along with inherited
challenges and their plausible solutions.