An Update on SARS-CoV-2: Damage-response Framework, Potential Therapeutic Avenues and the Impact of Nanotechnology on COVID-19 Therapy

COVID -19 Overview

Author(s): Anitha Sriram, Pravin Medtiya, Srushti Mahajan, Rahul Kumar, Dharmendra Kumar Khatri, Shashi Bala Singh, Jitender Madan and Pankaj Kumar Singh *

Pp: 1-15 (15)

DOI: 10.2174/9789815039863122010004

* (Excluding Mailing and Handling)


The appalling COVID-19 pandemic outbreak has become a major cause of mortality in 2020. The COVID-19 is caused by a dreadful coronavirus called nCoV (SARS-CoV2). The term “coronavirus” (CoV) originates from the Latin term corona, which means “halo”/ “crown,” as the virus carries the crown-like projections (spikes) on its surface. Coronaviruses are a large group of viruses causing mild diseases to severe respiratory and gastrointestinal diseases. This review describes the overview of COVID-19, including the origin and reservoir of SARS-CoV2 and the genomic sequence of SARS-CoV2 compared to other coronaviruses. Furthermore, major events of the COVID-19 outbreak, reported confirmed cases, death cases, and case fatality rate (CFR) of covid-19 since its beginning until now, and different facts about fatally potential beta coronaviruses are also discussed in detail in this review

Keywords: Beta coronaviruses, COVID-19, hACE2, nCoV, SARS, SARS-CoV2, SARS-CoV2 genome, Types of CoV.

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