SARS-coronavirus (SARS-CoV) originated in China from 2002 to 2003 and
caused a global outbreak with 8098 cases and 774 confirmed deaths. More than 15
years later, in less than a year, the new coronavirus (2019-nCoV) has infected more
than 44 million people and killed more than 1 million. The COVID-19 pandemic has
brought serious consequences for several countries and a worldwide alert about
coronaviruses. Severe acute respiratory syndrome (SARS) is an emerging infectious
viral disease characterized by severe clinical manifestations of the lower respiratory
tract that lead to severe lung damage and the spread of the virus to several other organs.
Phylogenetic analyzes demonstrate that SARS-CoV-2 shares a 79% identity with
SARS-CoV, and just as there was no effective treatment against SARS-CoV, it does
not yet exist against SARS-CoV-2. However, researchers from all over the world are
dedicating themselves to several studies in an attempt to find the best treatment and
prevention against the coronavirus. Thus, this book chapter addresses the main
characteristics of SARS, the main targets and drugs that have achieved excellent results
in clinical trials.