The Evolution of Radionanotargeting towards Clinical Precision Oncology: A Festschrift in Honor of Kalevi Kairemo

Dosimetric Approach to Radioactive Iodine Therapy of Differentiated Thyroid Cancer

Author(s): Hee-Seung Henry Bom *

Pp: 111-118 (8)

DOI: 10.2174/9781681088655122010012

* (Excluding Mailing and Handling)


My personal memory with Prof. Kalevi Kairemo is related to our coworking
for biokinetics of radioactive iodine (RAI), and a couple of international conferences
organized by him. I presented my data on the dosimetric approach of RAI treatment for
differentiated thyroid cancer (DTC) at the conference in Helsinki. We analyzed the data
of our work and published a paper. Here I summarize my experience of working with
him. In summary, maximum permissible dose (MPD) therapy with dosimetry is
effective for a selected group ofhigh-risk DTC patients. Calculation of MPD is feasible
either by tracer and therapeutic doses and either by blood clearance method and
metaphase analysis of peripheral blood lymphocytes. The use of recombinant thyroidstimulating
hormone (rhTSH) changes the biokinetics of RAI. It needs further
investigation whether rhTSH can be used for MPD therapy of DTC.

Keywords: Differentiated Thyroid Cancer, Dosimetry, Radioactive Iodine Treatment.

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