Smartphone Based Biosensors on Lateral Flow Assay Coupled to SERS: Point-of-Care Applications

Pp: 191-212 (22)

* (Excluding Mailing and Handling)

Point-of-care (POC) diagnostic analysis is a fast rising arena that goals to

improve the rapidness, low-cost, sensitive and selective in-vitro diagnostic analysis

platforms that are independent, moveable, and can be used everywhere from current

clinics to isolated and low resource regions. In addition, surface enhanced Raman

spectroscopy (SERS) offers a suitable sensory stage whereby objective particles at

smaller concentration are recognized, potentially identifying a particular substances.

There are some analytical methods which can induce motivated Raman scattering,

significantly attractive the possibility of Raman scattering, but most of these

procedures need ultra-fast tunable lasers and microscopy set-ups making them

impossible for most users. SERS exploits surface plasmons to improve Raman

scattering by numerous orders of magnitude, without lacking various equipment than

traditional Raman spectroscopy. As a result, SERS has been extensively useful in a

selection of research activities using various substrates, one of which is a smartphone

based biosensors. In outlining the development of SERS methods over the past few

years joined with new expansions in smartphone based biosensors, metal and metal

oxide nanomaterials, low-cost paper diagnostics, and high-quantity of microfluidics, a

wide-ranging number of novel potentials display the possible for decoding SERS

biosensors to the POC.

Keywords: Lateral Flow-assay, Point-of-care Application, Smartphone, Surface Enhanced Raman Spectroscopy.

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