Animal Models for Neurological Disorders

Progressive Experimental Screening Tools and Techniques for Parkinson's Disease: An Update

Author(s): Nitin Rawat, Hemprabha Tainguriya, Monika Kadian and Anil Kumar *

Pp: 78-93 (16)

DOI: 10.2174/9789815039689121010007

* (Excluding Mailing and Handling)


Parkinson's is the 2nd most common neurodegenerative disease in which symptoms range from several motor (rigidity, tremors, and bradykinesia) and nonmotor symptoms (cognitive impairment). These symptoms mainly arise due to alterations in dopaminergic pathways that disturb dopamine release, transmission, and storage. Animal models are employed to study human diseases to understand the disease's genetic and pathophysiological aspects. Several pathological conditions, such as the deposition of Lewy bodies, endoplasmic reticulum stress-induced unfolded proteins, and neuroinflammation, result in the degeneration of dopaminergic neurons. These reasons make the screening and evaluation of antiparkinsonian drugs more tedious and difficult. Animal model of Parkinson's includes neurotoxin model (MPTP, 6-OHDA, Paraquat, rotenone] and newer genetic model [α–synuclein, LRKK2, PINK). In this chapter, we have focused on the mode of action, advantages, and disadvantages of animal models of Parkinson's disease.

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