Cancer is a complicated family of diseases that causes major hurdles for
global health. Several studies on cancer biology and cancer treatment strategies have
revealed that cancer is highly genetically diverse and heterogenic in nature. The
complexity of cancer is due to the highly inflammatory microenvironment which
resembles wound healing process and highly acidic in nature. Hence, this condition is
referred as cancer related inflammation (CRI) that drives the cancer resistance and
subsequent recurrence of cancer after treatment. The major deregulated pathways
associated with CRI are nuclear factor kappa B (NF-κB) and phosphoinositol-3-kinases
(PI3-K) involved in cancer growth, proliferation, cancer cell survival and metastasis.
Therefore, the protein factors of these pathways seem to be an attractive target for the
molecular targetted therapy for cancer. However, efficient cancer treatment relies on
the stages of cancer and the response to the treatment. Hence, cancer specific
inflammatory components are the major targets for drug discovery, development and
associated clinical trials.
Keywords: Anti-inflammatory, Cancer related inflammation, Cancer treatment,
Cancer imaging, Cytotoxicity, Molecular target, Mitochondrial targeting,
Photoreactive, Targeted therapy.