Frontiers in Natural Product Chemistry

Volume: 7

Tetracyclic Benzocarbazoles and Derivatives: Synthesis and Applications

Author(s): Francisco Vilaça Gaspar, Joseane Alves Mendes, Paulo Roberto Ribeiro Costa, Miguel Yus, Francisco Foubelo and Camilla Djenne Buarque *

Pp: 158-196 (39)

DOI: 10.2174/9781681089164121070007

* (Excluding Mailing and Handling)


Tetracyclic benzocarbazoles are examples of nitrogen-containing heterocycles, which display interesting pharmacological activities and physicochemical properties. This chapter aims to bring some examples about the synthesis of bezocarbazoles, mostly benzo[a]carbazoles (including the dihydro and tetrahydro derivatives), with interesting properties. This chapter also includes aza-pterocarpans and aza-coumestans, which are structurally similar to benzo [a] carbazoles, although their analogous natural products are formed through different biosynthetic pathways. Being aware of the potential interest of these compounds, many efforts have been made for the development of new methodologies to carry out their synthesis and will be discussed below.

Keywords: Azaarylation, Aza-coumestans, Aza-pterocarpans, Azaspirodecanes, Benzocarbazoles, Chromanones, Chromene, Dihydronaphtalene, Fischer indol, Harmicine, Indole, N-tert-butanesulfinyl imine, Tetralone.

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