The success of Anti-infective agents (AIAs) is determined by the interaction
between a drug and the binding sites. Significant contributions have been made to the
synthetic and dynamic relationship between drugs and pharmacodynamics for the past
few years. In general, AIAs include antibacterial, antiviral, antifungal, and
antimicrobial agents, etc. The clinical benefit of using anti-infecting agents
significantly impacts bloodstream infections with central venous catheters (CVCs),
pregnancy, and lactation. Recent reports suggest income from AIGs formed 30.1% of
the total income of hospitality management. However, many more technical difficulties
remain, such as acquiring biologically relevant chemical diversity and achieving
activity across diverse pathogens, including highly challenging Gram-negative
pathogens with safe drugs. This chapter reviewed 1,2,4-triazoles, isatin, and coumarinbased
anti-infective agent developments from the past five years and their biological
studies against the various bacterial strains based on new challenges on viral and
bacterial infections and viruses. SAR studies also discussed the importance of hybrids
and substitutions in biology. We believe that this chapter helps future researchers to
develop the most effective and less toxic anti-infective agents.
Keywords: Anti-infective agents, Coumarin, Isatin, Toxicity, Triazole.
