This chapter proposes a brief description of the concept of pan-genomics;
Computation approaches in pan-genomics and challenges; Applications of pangenomics;
Evolutionary pan-genomics and its perspectives; Pan-genomics for cancer
prevention and its prospects; Pan-genomics of pathogens and its applications; Pangenome
analysis of microorganisms; Plant Pan-genomics.
Keywords: Microbial genome, Pan-genomics, Plant pan-genomics.