Dengue viral illness is communicated to humans through the bite of female
Aedes aegypti mosquitoes. This disease may become lethal in numerous patients. The
availability of an efficacious vaccine makes alarm for public healthcare. The dengue
virus multiplied inside the host framework involved many host-viral protein
interactions. This immunoinformatics study was designed for the prediction of immune
epitopes for T cell-mediated immunity. The epitopes are anticipated from the most
connecting viral protein with humans. We utilized a couple of epitope mapping tools
for the determination of immunodominant epitope for vaccine design. The physical
interaction between epitope ligand and receptor MHC class I alleles was analyzed in
the molecular docking study. This study was concluded that two epitopes
(‘SRAIWYMWL’ and ‘FLEFEALGF’) are suitable for the designing of an efficacious
multi-epitope vaccine. The clinical validation is considered necessary for the final
confirmation of vaccine potency.
Keywords: Conservancy, Dengue, Epitope, Host, Immunogenicity,
Immunoinformatics, Protein-interaction, Vaccine, Virus.
