Advances in Organic Synthesis

Volume: 15

Functionalized Catalyst for Efficient Nucleophilic and Electrophilic Fluorination

Author(s): Sandip S. Shinde *

Pp: 124-150 (27)

DOI: 10.2174/9789814998482121150005

* (Excluding Mailing and Handling)


Fluorination reactions are an important class of organic synthesis. Fluorine is a highly electronegative atom; thus, it has dual characteristics, such as being basic and nucleophilic in nature which produces various products. In this chapter, we have discussed the recent development of fluorination methods by using various phase transfer catalysts. The catalyst plays a significant role in aliphatic nucleophilic fluorination. The various tasks of specific tailor-made ionic liquids are developed and used for fluorination reactions. Ionic liquid catalyst is immobilized, covalently bonded on solid or liquid support to improve the catalytic efficiency in the reactions.

Keywords: Aliphatic nucleophilic substitution, Catalyst, Electrophilic, Fluorination, Halogenations, Ionic Liquids, Methodologies, Organic reactions.

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