Coronavirus undergoes more frequent mutations over time. It is well
understood with previous outbreaks of the diseases, like the severe acute respiratory
syndrome (SARS) and the Middle East respiratory syndrome-coronavirus (MERSCoV).
The behavior and pattern of diseases change with the mutation, and the virus
becomes a new virus of its out kind regarding morbidity and mortality. Virus from
different origins has been observed to have mutations at various places of their genome
resulting in changed disease pattern resulting in the worldwide outbreak of the
coronavirus disease-19 (COVID-19). Mutation in coronavirus is a slow and emerging
process that may be responsible for the modulation of viral transmission, virulence, and
replication efficiency in different regions of the globe. SARS-CoV-2 is going to spread
around the world, and novel mutation hotspots are emerging in the genome. There has
been increasing in the genetic diversity of coronavirus in human hosts. Random
mutations cause the diversification of the virus leading to drug resistance, the changed
pathogenicity and infectivity. This variation could remain in the virus, but it could be
transferred to the next generation. The study was conducted to focus on viral evolution
through mutation in various geographic regions of the world.
Keywords: Coronavirus, COVID-19, Genome, Mutation, SARS-CoV-2.