Coronaviruses (CoVs) are members of the Coronaviridae family that
possess positive-sense RNA. These are enveloped viruses causing severe acute
respiratory syndrome (SARS), the Middle East respiratory syndrome (MERS), and
currently coronavirus disease-19 (COVID-19) in humans. Still, there is less
information available about the biology of Severe Acute Respiratory Syndrome-
Coronavirus-2 (SARS-CoV-2). Recently, it was suggested that endocytosis mechanism
studies and autophagy implicate importance in the viral entrance and an infection.
These suggestions ascertain that endocytosis and intracellular trafficking studies have
become essential target sites for developing therapeutic approaches. Initially, it was
thought that coronaviruses possibly enter the host cell through direct diffusion, evading
the membrane barriers. Laterally, it was found that the virus may enter the cell through
the mechanism of endocytosis. Entry pathways and endocytosis of other viruses and
especially SARS-CoV discussed here may expand the cellular range of viral
endocytosis studies, pathogenesis, and infection. It may provide new information for
pharmacokinetic studies and vaccine development. This chapter discussed some current
advances in our understanding of cellular pathways of SARS-CoV-2 attachment,
molecular signaling during virus entry, and trafficking mechanism studies.
Keywords: Coronaviruses, COVID-19, Clathrin, Endocytosis, SARS-CoV.