The heart of adult humans is usually less capable of regeneration; several
strategies have been used for the repairment of a damaged heart and to recover its
function. However, stem cell technology showed a promising approach for cardiac
therapy. More advanced strategies are used for improved stem cell-mediated cardiac
regenerative therapy and to develop vascularization between scaffold (established by
3D engineered techniques) and host hearts. Through understanding the cellular and
molecular mechanisms regulating heart regeneration, considerable progress has been
made, which offers potentiality in controlling cardiac remodeling and redirecting the
adult human heart towards a regenerative state.
Keywords: Cardiac regeneration, Cardiomyocytes, Mesenchymal stem cells,
Pluripotent stem cells, Scaffold.
