Various lifestyle related factors are primarily responsible for the increase of cardiovascular diseases. The development of numerous diseases such as acute myocardial infarction, stroke and thrombosis need multiple therapies. These therapies are based on synthetic active ingredients, which in long-term usage, give adverse side effects. Currently, a lot of attention has been focused on nanotechnology based drug formulation, which can provide sustained drug release, increased half-life, and in turn, can circumvent limitations of conventional therapies. With the advent of the nanomedical approach, the survival length of the patients can be prolonged. This chapter mostly focuses on widely used nanomedicines in therapy and imaging of cardiovascular diseases.