Worldwide, cardiovascular diseases claim a number of lives; however, some of them are preventable with an early and proper management. Still, the treatment of cardiovascular diseases is limited as it deals with prescribed medicines administered orally and under critical condition with invasive surgery. Due to this, there exists an enormous gap in the area of medicine for the development of therapies for better patient outcomes. In this regard, recently, nanotechnological aspects of the development of medicines are sought, which may provide a solution for more effective treatment of disease, having better therapeutic outcomes with reduced side effect profile. Further, the regenerative nanomedicine therapeutic approach opens up a paradigm that deals with the repair of damaged heart tissue and future potential use of such systems.