Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belongs to
the coronavirus family and is responsible for coronavirus disease 2019 (Covid-19 is a
new animal origin communicate or infectious disease). The first case of Covid19 was
reported in Wuhan, China, in December 2019, and due to its rapid increase and high
incidence rate, it has become a pandemic health problem worldwide. It mainly attacks
the host's immune system and impairs the regulation system, playing a significant role
in its pathogenesis, causing covid-19 disease. Still, we are waiting for such molecules
that can act as immunomodulators and enhance the body's immune system against the
disease. This literature-based chapter was prepared by searching numerous relevant
SCI and SCOPUS articles on the SARS-CoV-2 and COVID-19, herbal formulation and
its active molecules from different databases like- Google Scholar, PubMed, and
ResearchGate. Here, we were trying to highlight or repurpose several
Immunomodulators (Alkaloids, Glycosides, Flavonoids, Sapogenins, and Curcumin) of
plant origin. Plant-derived Immunomodulators are capable of stimulating/suppressing
the components of the host immune system and both innate and adaptive immune
responses. However, in this present review, we will discuss some phytoactive
chemicals, which act as immunomodulators, and their immunomodulation mechanism
in the host. Hopefully, this work shall encourage the researcher community to
undertake further work on plant-based antiviral therapy with potential
immunomodulatory activity, which might be responsible for modulating the host
immune system to cure Covid-19. Besides, we discuss the further prospect of this
study.
Keywords: Alkaloids, COVID-19, Curcumin, Flavonoids, Glycosides,
Immunomodulators, Medicinal plants, SARS-CoV-2, Sapogenins.
