The novel epidemic of zoonotic origin coronavirus disease (COVID-19) outbreak from wet market Wuhan, Hubei province of China became one of the massive eruptions toward humanity in 2020. In the present scenario, the World Health Organization declared the coronavirus outbreak as a public health pandemic. Researchers have been trying to develop vaccines and drugs against SARS since its outbreak, but no licensed treatments and vaccines are available. So, in the epidemic situation, consequently precautions measures are the only solution to prevent the spread of this virus. Scientists are struggling for vaccine development against COVID-19 that mainly targets the surface protein (S), the major inducer for neutralizing antibodies. Although few aspirants are also working for in vitro studies and many clinical trials are going on throughout the world. This chapter summarised the on-going challenges in the development of vaccines and specific drugs against SARS 2 along with future prospects.