Herbals are used from ancient times for the treatment of various body ailments. These are also used in the treatment of various infectious diseases, including viral infection. Recently, COVID-19 viral infection has emerged and spread across the globe. Currently, no specific drugs are available in the treatment of this infection. Thus, there is a need for specific drugs or herbal molecules against this infection. This chapter summarized potential antiviral herbals that could be effective in the treatment of COVID-19 infection. Further, the proposed mechanism of action of these herbals against COVID-19 has also been discussed. Finally, this chapter concludes with current challenges and the future perspectives of using herbals against COVID-19 infections.