Recently, the World health organization (WHO) has declared COVID-19 as a global health emergency as it is spreading almost all over the world. The number of infections to death ratio related to COVID-19 is varying in different countries, yet endangering human survival. Currently, no specific treatment is available, thus, there is a need for specific drugs against SARS-CoV-2. To develop specific drugs, specific targets should be identified. Thus, this chapter summarizes potential targets in SARSCoV- 2.