Many COVID-19 patients die not just because of the virus but also due to the patient’s own immune system responding in an exaggerated manner called “Cytokine Storm”. This stormy strong immune response not only just kills the virus but also kills the patients. The interaction of COVID-19 with the immune system is poorly understood. Recently, some studies have indicated the alteration of innate and adaptive immune signalling pathways after COVID-19 infection. Thus, in this chapter, we have compared the normal immune signalling pathways with COVID-19 altered immune signalling pathways, which will help the researchers in the designing and development of specific drugs or vaccines against this virus.