In the beginning of the 21st century, many viral infections were reported with a significant impact on the socio-economic growth of many nations globally. Many new strains of viruses were reported in the recent past. Passive antibody therapy involves antibody administration against various viruses. Though vaccines are available for many diseases, however, a longer duration is required for the development of a vaccine for novel viruses like the COVID-19 outbreak. In such cases, passive antibody therapy plays a major role in providing instantaneous immunity to susceptible persons. Proofs predicted that patients receiving convalescent plasma recovered from the disease and utilized it as a treatment without any serious antagonistic occasions. In this manner, it may be beneficial to test the safety and adequacy of convalescent plasma transfusion in SARS-CoV-2 contaminated patients. In this chapter, the authors conducted a brief literature review on treatment options against novel coronavirus. This chapter emphasized on the use of plasma therapy against novel Coronavirus and its future perspectives.