In-Silico and In-Vitro Approaches to Screen the Antituberculosis Activity of Benzothiazole Analogs

Mycobacterium Tuberculosis and In-Vitro Methods for Screening Anti-TB Drugs

Author(s): Mahesh Bhat, S.L. Belagali, B. Manohara and S.V. Mamatha

Pp: 44-65 (22)

DOI: 10.2174/9789811494635121010006

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Tuberculosis is a most infectious dangerous health problems caused by the Mycobacterium tuberculosis, the species mainly affects the lungs, it can also spreads to various parts of the body like the brain and the spine and second biggest killer in the world. In this chapter, we have discussed about the Mycobacterium tuberculosis and its various types and symptoms of the tuberculosis diseases. Detailed history of the evolution of the tuberculosis treatment has been discussed, followed by the prominent drug molecules and their classification. To screen the molecules to tuberculosis, different methodologies are required; here various in-vitro and in-vivo methods have been discussed in-order to evaluate the drug capacity against the tuberculosis.

Keywords: Alamar Blue assay, Benzothiazole, Dubos broth Pyrazinamide, invitro, in-vivo, H37Rv strain, Ligand, LJ media, McFarland, MDRX, MTT assay, Nitroimidazole, Pyrazinamide, Pyrrole, PZase, Resazurin, Rifampicin, Streptomycin, Tuberculosis.

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