Microbial metalloproteomics involves a detailed analysis of the proteins that
have metals as an important part or known to bind to metals in biological samples.
Recent updates showed that metalloproteome helps in understanding the role of
different environments/conditions in the survival of microbes and is involved in
microbial pathogenesis. Microbial metalloproteomics could also be used in
understanding the resistance mechanisms of microbes. We have explored different
metalloproteomic approaches such as inductively coupled plasma-Mass spectroscopy
(ICP)-MS, X-ray absorption/fluorescence, radionuclide, and bioinformatics. We have
also discussed the role of metalloproteins such as metallo-beta-lactamases in microbial
drug resistance, the alternation of the microbial proteome in response to the metal, and
their role in host-pathogen interactions. We have also surveyed different therapeutics
targeting the microbial metalloproteins. Current advancements in the metalloproteome
would help in understanding the mechanism better and the adequate role of
metalloenzymes and proteins in conferring the drug resistance in microbes.
Keywords: Host-pathogen interaction, ICP-MS, Metalloproteome, Metallo-beta
lactamases, Metalloproteomic approaches, Metal inducible proteome, Microbial
drug resistance, Microbial therapeutics, X-ray absorption.