Antimicrobial resistance (AMR) remains one of the major global public health threats today. Infections due to multi-drug resistant organisms have been shown to not only increase healthcare costs but also be a significant cause of morbidity and mortality in patients. Global efforts have been employed to combat the issue of AMR. Specifically, the World Health Organization’s global action plan on antimicrobial resistance recognizes key areas to be addressed including: increased awareness and understanding of AMR, infection prevention and control, enhanced structure with the use of antimicrobials in animals, research, and economic investment in intervention methods. Several approaches exist to help mitigate this issue such as the development of antimicrobial stewardship programs (ASPs), clinician education, improved infection control practices and judicious antibiotic use in animals. This chapter will outline many of the current strategies proposed to counter and prevent the global concern of AMR.