Vascularization in Tissue Engineering

Angiogenesis and Materials

Author(s): Xin Qin, Yuting Wen and Xiaoxiao Cai

Pp: 102-129 (28)

DOI: 10.2174/9789811475849120010008

* (Excluding Mailing and Handling)


In the process of tissue engineering vascularization, as one of the three major factors of tissue engineering, scaffold materials play a vital role in the various processes of vascularization. As a starting point, this chapter first introduces the reader to several strategies for scaffolding materials to promote vascularization. It basically describes the reasons for the use of scaffold materials in vascularization and the necessity of scaffold materials in tissue engineering vascularization. Then we will focus on how to properly use the scaffold material. The design of the scaffold material itself is a key factor in the function of the material, and the scaffold material with ideal biological properties can make the process of vascularization more effective. Factors such as the topology of the material and the physical and chemical properties of the material affect the success rate of vascularization to varying degrees. We hope that readers can obtain the basic knowledge and principles of stent design from this chapter. Finally, a number of fresh ideas have emerged for the design of tissue engineered vascular materials, such as new material handling methods, new ways of combining cells, and so on, which have improved the vascularization process to varying degrees. Scaffold materials have shown attractive prospects and great possibilities in vascular tissue engineering. Previous studies have found many materials associated with vascularization, but there are also many problems to be solved. With the development of materials science and engineering, it is believed that there will be new vascular stent materials with better performance and more suitable for vascularization in the future.

Keywords: Angiogenesis, Degradation Modes of Scaffold, Materials, Tissue Engineering Vascularization.

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