Nowadays, researchers concentrated on the advancements of new types of precision actuators to satisfy the increasing demand for high precision positioning technology. Owing to fast response, high precision, and compact structure, the piezoelectric actuators attracted much attention. In the advancement of science and technology, the ceramics play a vital role. In this chapter, we mainly focussed on applications of piezoelectric actuators in different fields such as nano metrology, and industries. Even, the different advanced ceramics for piezoelectric actuators were discussed.