Deep vein thrombosis is a serious health problem due to thrombosis in the systemic circulation. Ineffective treatment of deep vein thrombosis increases the risk of pulmonary embolism. Venous thrombosis condition decreases the blood flow to the veins in the legs. Valves help to promote the blood flow to the veins, during the hypoxia condition the low level of the blood flow to the veins can manifest the symptoms of venous thrombosis. The incidence of deep vein thrombosis is estimated to one patient per 1000 cases annually. The clinical manifestations of venous thromboembolism include swelling; redness can increase the progression of venous thromboembolism. The blood test, doppler ultra sound, venogram and magnetic resonance imaging test are helpful for the detection of deep vein thrombosis. The pharmacological and non-pharmacological treatment modalities are encouraged in the inpatient and outpatient wards could useful for reducing the progression of disease complications.