Cardiovascular diseases cause more deaths in the world. Atherosclerotic plaques cause thrombus formation in the blood vessels leads to impediment in the vascular lumen can create a complete blockage of the blood vessels which increases the risk of developing coronary artery disease. The biomarker is used to assess the biological process and pharmacological responses of the drugs to a targeted intervention. It is used to identify the disease progression burden among the affected population. The cardiovascular biomarkers include B-type natriuretic peptide, urinary NGAL, troponin, C-reactive protein, N-terminal prohormone BNP, myeloperoxidase, lipoprotein-associated phospholipase A2, cytokine IL-37, troponin, fibrinogen, metalloproteinase-1, and cystatin C is used to predict the risk of progression of cardiovascular diseases.