Frontiers in Lung Cancer

Biology and Molecular Evolution of Lung Cancer

Author(s): Sean B. Knight

Pp: 21-44 (24)

DOI: 10.2174/9789811459566120010004

* (Excluding Mailing and Handling)


Lung cancer is the worldwide leading cause of cancer-related deaths [1]. At a fundamental level, understanding the important molecular and cellular events that lead to lung cancer is critical for developing treatments to reverse this statistic. This chapter reviews the progress and limitations of our current understanding of lung cancer. It describes the initiation and progression of lung cancer from carcinogeninduced mutation of DNA to tumour formation and metastases.

Keywords: Cancer evolution, Circulating tumour cells, Driver mutation, Epithelial to mesenchymal transition, Malignant transformation, Metastases, Lung cancer, Immune evasion.

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