Frontiers in Cardiovascular Drug Discovery

Volume: 4

Should the Argument About Aspirin Dosing be About Frequency Rather the Dose?

Author(s): Nicholas B. Norgard, Priya Jain and Jonathon R. Enriquez

Pp: 1-15 (15)

DOI: 10.2174/9781681083995119040003

* (Excluding Mailing and Handling)


Aspirin is known to have inter-individual variability in its pharmacodynamic response. Clinical investigators continue their empirical search for the optimum aspirin dose to safely prevent athero-thrombosis. Several patient populations have an accompanied accelerated platelet turnover that is associated with a time-dependent loss of aspirin efficacy. Increasing the dosing frequency has been shown to elicit better and more sustained platelet inhibition compared to a dose increase in these patient populations. This review explores the role of accelerated platelet turnover in aspirin pharmacodynamics and the benefits of multiple daily aspirin dosing.

Keywords: Antiplatelet, Aspirin, Essential Thrombocythemia, High On-Aspirin Platelet Reactivity, Platelet Turnover.

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