Genital HPV infections are the most common of all sexually transmissible
agents. The HPV life cycle is dependent on host cell differentiation with late viral
events such as structural gene expression and viral genome amplification in the upper
layers of the stratified epithelium. Indeed, the virus destabilizes host chromatinremodeling
factors to facilitate viral replication and transcription. Generally, the life
cycle of the virus is divided into major steps including entry, establishment of the nonproductive
infectious state, maintenance of the non-productive infectious state, and
productive stage. In this chapter, we briefly explain transmission and the life cycle of
HPVs in host cells.
Keywords: HPV infection, Life cycle, Transmission.
