Climate change is affecting biodiversity and overall system functioning of all the worlds’ oceans. Over the past decades, significant amount of evidence has accumulated which allow us to decipher its effects on the Adriatic Sea. Investigations of fish communities in its eastern part showed us that it has undergone a significant biodiversity changes which are dominated by the influx of alien fishes, distributional shifts of native fishes and community-level changes of native populations of fishes. These changes have profound influence on fishery and aquaculture of the eastern Adriatic Sea. Beside current state, potential future scenarios which will affect its fish and fisheries are reviewed.