Advances in Physicochemical Properties of Biopolymers (Part 2)

Approaches for Improving the Mechanical Properties of Collagen Biomaterials

Author(s): María Victoria Tuttolomondo, Maria Lucia Foglia, Juan Manuel Galdopórpora and Martin Federico Desimone

Pp: 354-370 (17)

DOI: 10.2174/9781681085449117010011

* (Excluding Mailing and Handling)


Collagen is a natural constituent of the extracellular matrix of tissues. It is well known that, when prepared without additives, diluted collagen hydrogels present poor mechanical properties limiting their use in tissue engineering. Hence, collagen's structural properties need to be enhanced. For this purpose, this chapter presents an overview of the recent advances and alternatives developed to improve the mechanical properties of collagen biomaterials.

Keywords: Biomaterial, Collagen, Crosslink, Fibrils, Hydrogel, Mechanical properties, Thermal stability, Tissue engineering, Wound healing.

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