2,6-Disubstituted piperidinols are one of the most investigated groups of
compounds owing to their potential therapeutic use and unique structures. They show a
wide variety of biological activities, including inhibition of superoxide anion
production, influence on the central nervous system, antibacterial, and plant growth
inhibition. For these reasons, 2,6-disubstituted piperidinols have attracted attention
from medicinal, phyto-, and synthetic organic chemists. In this review, the biological
profile and chemistry of 2,6-disubstituted piperidinols are described. Recent
developments in synthetic methods for 2,6-disubstituted piperidinols are also discussed.
Keywords: 2, 6-Disubstituted piperidinols, Antibacterial, Antiparasitic, Bioactive
compounds, DNA-damaging, inhibitor, Fucosidase, Nervous system, Synthesis,
Plant growth.
