Simulation is applied to exhibit the extent of how the offered valuable functionalities of given issues are appreciated. A systematic glossary of about twenty types of intelligence provides a synoptic background for intelligent behavior that can be represented by agents. The three categories of the synergy of simulation and software agents are discussed in the following three sections: agent simulation, agentsupported simulation, and agent-monitored simulation. Extensive bibliographic analysis which is based on about 440 references supports each category of the synergy of simulation and software agents. Discussion of some desirable research directions and a conclusion section terminate the article.
Keywords: Agent-directed simulation, Agent-monitored simulation, Agent simulation, Intelligence, Software agent, Supported simulation.