Frontiers in Drug Discovery

Volume: 2

Oxidative and Nitrosative Stress, Immune Inflammation and Trptophan Catabolites in Driving Melatonergic Pathway Alterations in Depression: Treatment Implications

Author(s): George Anderson and Michael Maes

Pp: 222-241 (20)

DOI: 10.2174/9781681084732117020012

* (Excluding Mailing and Handling)


In this chapter we review the interactions of oxidative and nitrosative stress (O&NS), immune-inflammation, tryptophan catabolites (TRYCATs) and suboptimal mitochondrial functioning in driving changes in the melatonergic pathways in major depressive disorder (MDD). We propose that such interactive biological processes provide a framework for the development of a number of novel pharmaceutical and nutriceutical treatment targets, with relevance to a classification of MDD that is based on biological underpinnings rather than on subjective phenomenology.

Keywords: Inflammation, Major depressive disorder, Mitochondria, Nitrosative stress, Oxidative stress, Tryptophan catabolites.

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